![]() The first modification of the tetrasaccharide linker determines whether the HSGAGs or CSGAGs will be added. Construction of a tetrasaccharide linker that consists of -GlcAβ1–3Galβ1–3Galβ1–4Xylβ1-O-(Ser)-, where xylosyltransferase, β4-galactosyl transferase (GalTI),β3-galactosyl transferase (GalT-II), and β3-GlcA transferase (GlcAT-I) transfer the four monosaccharides, begins synthesis of the GAG modified protein. HSGAG and CSGAG modified proteoglycans first begin with a consensus Ser-Gly/Ala-X-Gly motif in the core protein. The fourth class of GAG, hyaluronic acid, is synthesized by integral membrane synthases, which immediately secrete the dynamically elongated disaccharide chain. Keratan sulfate may modify core proteins through N-linked glycosylation or O-linked glycosylation of the proteoglycan. Heparin/ heparan sulfate (HSGAGs) and chondroitin sulfate/ dermatan sulfate (CSGAGs) are synthesized in the Golgi apparatus, where protein cores made in the rough endoplasmic reticulum are post-translationally modified via O-linked glycosylation by glycosyltransferases ,forming proteoglycans. GAGs are classified into four groups, based on their core disaccharide structures. This is because GAG synthesis is not template driven, as are proteins or nucleic acids, but constantly altered by processing enzymes. Kim could try asking the court fora gag order restricting both partiesfrom airing their grievances publicly during the divorce, but I doubt she would be successful, free speech is valued in this country, and Kim would have to show a risk of grievous harm in order to be successful.Glycosaminoglycans vary greatly in molecular mass, disaccharide structure, and sulfation. He hit some really heavy subjects but then brought you out of that emotional moment with a cutting gag. Title X clinics, such as Planned Parenthood, provide essential services now they can keep serving women while we continue to fight to keep the federal government out of the exam room. Todays ruling ensures that clinics across the nation can remain open and continue to provide quality, unbiased healthcare to women, trumps gag rulewould have jeopardized healthcare access to women across the country. Occasionally a cloth over-the-mouth gag is used not to prevent speech but to keep dust and aerosols out of the lungs.Īuthorities ought to protect, not gag journalists on the job. Very rarely, courts have been known to gag unruly defendants Bobby Seale was the most famous case. It it also often used in movies, such as Raiders of the Lost Ark and its sequel Indiana Jones and the Kingdom of the Crystal Skull. The use of gags is commonly depicted in crime fiction, particularly in comics and novels. The more "effective" a gag appears to be, the more hazardous it is: for example, duct tape is fairly effective but is hazardous if for some reason the subject cannot breathe freely through the nose. They carry a strong risk of killing the victim by suffocation. They are often less effective in reality than in crime fiction. ![]() This is usually done by blocking the mouth, partially or completely, or attempting to prevent the tongue, lips, or jaw from moving in the normal patterns of speech. Make an unsuccessful effort to vomit strain to vomitįreebase (0.00 / 0 votes) Rate this definition:Ī gag is usually a device designed to prevent speech, often as a restraint device to stop the subject from calling for help. Struggle for breath have insufficient oxygen intake "The students were gagging during dinner" "The burglars gagged the home owner and tied him to a chair" Tie a gag around someone's mouth in order to silence them Restraint put into a person's mouth to prevent speaking or shouting "he told a very funny joke" "he knows a million gags" "thanks for the laugh" "he laughed unpleasantly at his own jest" "even a schoolboy's jape is supposed to have some ascertainable point" Princeton's WordNet (0.00 / 0 votes) Rate this definition:Ī humorous anecdote or remark intended to provoke laughter
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